179535-17-2

Upstream product

• 74-89-5 methylamine 
• 179535-12-7 4-chloro-N-(1-ethyl-1H-hexahydroazepin-3-yl)-2-methoxy-5-nitrobenzamide 
• 90763-47-6 4-Chloro-2-methoxy-5-nitro-benzoyl chloride 
• 68255-77-6 2-methoxy-4-chloro-5-nitrobenzoic acid 

Downstream Products

• 179535-18-3 5-amino-N-(1-ethyl-1H-hexahydroazepin-3-yl)-2-methoxy-4-methylaminobenzamide 

Relevant academic research and scientific papers

6-methoxy-1H-benzotriazole-5-carboxamide derivatives and pharmaceutical compositions containing them

6-Methoxy-1H-benzotriazole-5-carboxamide derivatives which are represented by the formula (I) below: STR1 ?in which R1 stands for ethyl or cyclopropylmethyl group, R2 stands for hydrogen atom, methyl or ethyl group, n is 1, 2 or 3, a

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with a medium perhydroazacycle ring in the amine moiety were prepared, and their antiemetic and gastroprokinetic activities were evaluated. Among them, N-(1-ethylhexahydroazepin-3-yl)-, N-(1-ethyloctahydroazocin-3-yl)- and N-(1- ethyloctahydroazonin-3-yl)-6-methoxy-1H-benzotriazole-5-carboxamides (24, 36, 37) showed a potent antiemetic activity (inhibition of apomorphine-induced emesis in dogs) along with gastroprokinetic activity (gastric emptying in rats).