179536-77-7

Upstream product

• 56069-39-7 diethyl phenylsulfonylmethylphosphonate 
• 179536-74-4 ethyl (4aS,6R,8aR)-(+)-hexahydro-2,2-dimethyl-5-(phenylmethyl)-4H-1,3-dioxino-[5,4-b]pyridine-6-but-(2E)-enoate 
• 179536-73-3 2-((4aS,6R,8aR)-5-Benzyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyridin-6-yl)-ethanol 
• 179536-76-6 (4aS,6S,8aR)-6-((E)-5-Benzenesulfonyl-pent-4-enyl)-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyridine-5-carboxylic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 179536-78-8 (3R,4S,6S,9aS)-(-)-4-{[(2,2-dimethylethyl)diphenylsiloxy]methyl}-3-hydroxy-6-(phenylsulfonylmethyl)-octahydro-2H-quinolizine 
• 179536-79-9 (3R,4S,6S,9aS)-(-)-{[(2,2-dimethyl)diphenylsiloxy]methyl}-3-(methoxymethoxy)-6-(phenylsulfonylmethyl)octahydro-2H-quinolizine 
• 179536-80-2 (3R,4S,6S,9aS)-(-)-4-(hydroxymethyl)-3-(methoxymethoxy)-6-(phenylsulfonylmethyl)-octahydro-2H-quinolizine 
• 179536-81-3 (3R,4S,6S,9aS)-(+)-4-(iodomethyl)-3-(methoxymethoxy)-6-(phenylsulfonylmethyl)-octahydro-2H-quinolizine 
• 179536-82-4 (3R,4S,6S,9aS)-(-)-3-(methoxymethoxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-2H-quinolizine 
• 132621-83-1 (-)-clavepictine A 
• 132621-84-2 (3R,4S,6S,9aS)-6-((1E,3E)-deca-1,3-dienyl)-4-methyl-octahydro-quinolizin-3-ol 
• 1053244-37-3 (3R,4S,6S,9aS)-6-Benzenesulfonylmethyl-4-hydroxymethyl-octahydro-quinolizin-3-ol 

Relevant academic research and scientific papers

Total synthesis of clavepictines A and B. Diastereoselective cyclization of δ-aminoallenes

The stereocontrolled total synthesis of (-)-clavepictine A (1A) and (+)- clavepictine B (1B) has been accomplished in an enantioselective fashion, which has unequivocally established the absolute configuration of 1A and 1B. The pivotal step in the synthes

Highly stereoselective construction of 4,6-cis-substituted quinolizidine ring core: An application to enantioselective total synthesis of the marine alkaloid clavepictines A, B and pictamine

The enantioselective total synthesis of the marine alkaloids clavepictines A, B and pictamine has been achieved through the highly stereocontrolled quinolizidine ring closure of the conformationally constrained piperidine ring system (2), which bears the chiral centers and appropriate functionality needed for the synthesis of target alkaloids. The absolute stereochemistry of clavepictines and pictamine was verified to be 3R, 4S, 6S, 9aS by the present synthesis.