179548-99-3Relevant academic research and scientific papers
Synthesis of a dihydropyranonucleoside using an oxidative glycosylation reaction mediated by hypervalent iodine
Kan-No, Hiroya,Saito, Yukako,Omoto, Shun,Minato, Sakie,Wakamatsu, Hideaki,Natori, Yoshihiro,Imamichi, Tomozumi,Takahata, Hiroki,Yoshimura, Yuichi
, p. 879 - 886 (2014)
As a part of our ongoing studies of structure-activity relationships regarding cyclohexenyl nucleosides, we were prompted to synthesize a dihydropyranonucleoside as a potential anti-HIV agent. The synthesis of a glycal moiety started from but-2-enediol, which was converted into a di-PMB derivative in several steps. The introduction of an allyl group followed by ring-closing metathesis gave a dihydropyran derivative. After isomerization of the double bond catalyzed by Wilkinson's catalyst, the resulting glycal, 2,3-bis[(4-methoxybenzyloxy)methyl]-3,4-dihydro-2H-pyran, was subjected to an oxidative glycosylation reaction mediated by hypervalent iodine. Treatment of 2,3-bis[(4-methoxybenzyloxy)methyl]-3,4-dihydro-2H-pyran with (PhSe) 2/PhI(OAc)2/TMSOTf (cat.) gave the desired pyranyluracils as a mixture of anomers that were converted into the final target, dihydropyranocytidine, after several manipulations and separation of the anomers. Georg Thieme Verlag Stuttgart. New York.
A short convergent synthesis of the [3.2.1]dioxabicyclooctane subunit of sorangicin A via regioselective epoxide opening
Raghavan, Sadagopan,Nyalata, Satyanarayana
, p. 1071 - 1077 (2018/02/10)
In this paper, we disclose the synthesis of the dioxabicyclo[3.2.1]octane subunit of the potent antibiotic sorangicin A. The synthesis was achieved in a convergent manner in 8 steps. Regio- and stereoselective intermolecular epoxide opening, ring-closing metathesis and iodo-etherification are key steps. cis-2-Butene diol has been employed as a common staring material.
Stereoselective synthesis of the C13-C28 subunit of (-)-laulimalide utilizing an α-chlorosulfide intermediate
Raghavan, Sadagopan,Samanta, Pradip Kumar
supporting information, p. 1983 - 1987 (2013/09/24)
A stereoselective route to the C13-C28 subunit of (-)-laulimalide is described. l-Tartaric acid is the source of the hydroxy groups at C19 and C20. An α-chlorosulfide is employed as the key intermediate for the creation of the C17-C18 bond and the C16-C17 double bond was introduced using the Mislow-Braverman rearrangement and Hutchin's dexoxygenation with concomitant double bond transposition reaction. The C15 and C23 stereogenic centers were created using catalytic asymmetric reactions. The trisubstituted and trans-disubstituted alkenes were created stereoselectively by taking advantage of ring-closing metathesis and the Julia-Kocienski olefination reaction, respectively. Georg Thieme Verlag Stuttgart, New York.
A very practical and selective method for PMB protection of alcohols
Chavan, Subhash P.,Harale, Kishor R.
experimental part, p. 4683 - 4686 (2012/09/05)
A very simple, practical and efficient one-step heterogeneous protocol for the PMB protection of alcohols using Amberlyst-15 has been developed. The stability and hazard issues regarding PMBCl and PMBBr are totally avoided by directly using anisyl alcohol for the protection. Alcohols are protected in very good yields. The selective mono-PMB protection of diols as well as di-PMB protection of diols was achieved in good yields, along with the demonstration of recyclability of the catalyst.
Stereoselective total synthesis of (+)-sapinofuranone B
Yadav,Mandal,Reddy,Srihari
experimental part, p. 4620 - 4627 (2011/07/08)
Two approaches for the total synthesis of (+)-sapinofuranone B have been described. The first strategy utilizes the methodology developed earlier in our group to get the chiral propargyl alcohol and the second strategy involves generation of threo-1,2-diol derivative by diastereoselective and enantioselective addition of [(Z)-γ-methoxymethoxyallyl] diisopinocampheylborane onto aldehyde and cross metathesis as the key steps.
Structure assignment of lagunapyrone B by fluorous mixture synthesis of four candidate stereoisomers
Yang, Fanglong,Newsome, Jeffery J.,Curran, Dennis P.
, p. 14200 - 14205 (2008/02/10)
Techniques of fluorous mixture synthesis have been used to make four candidate stereoisomers for the natural product lagunapyrone B. A quasiracemic mixture of vinyl iodides whose component configurations at C19-21 were encoded by fluorous silyl groups was
Construction of a C(30-38) dioxabicyclo[3.2.1]octane subtarget for (+)-sorangicin A, exploiting a regio- and stereocontrolled acid-catalyzed epoxide ring opening
Smith III, Amos B.,Fox, Richard J.
, p. 1477 - 1480 (2007/10/03)
In this paper, we report assembly of the novel dioxabicyclo[3.2.1]octane subtarget (-)-2, comprising the signature structural element of the potent antibiotic (+)-sorangicin A (1). The synthesis was achieved in 15 steps (1.5% overall yield) via a series o
