179626-17-6

Basic information

• Product Name: 2-amino-N-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide
• Synonyms: 2-amino-N-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide
• CAS NO: 179626-17-6
• Molecular Weight: 447.364
• Mol File: 179626-17-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-amino-N-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide(179626-17-6)
• EPA Substance Registry System: 2-amino-N-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide(179626-17-6)

Safety Data

• Hazardous Substances Data: 179626-17-6(Hazardous Substances Data)

Upstream product

• 167834-48-2 8-hydroxy-2-methyl-4-dimethylaminoquinoline 
• 90-04-0 2-methoxy-phenylamine 
• 33267-45-7 ethyl 3-<(2-methoxyphenyl)amino>but-2-enoate 
• 64951-58-2 4-chloro-8-methoxy-2-methylquinoline 
• 15644-89-0 8-methoxy-2-methyl-4-quinolinol 
• 28507-46-2 4-chloro-8-hydroxy-2-methylquinoline 
• 179626-14-3 N-[2,4-dichloro-3-({[4-(dimethylaamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide 
• 167837-49-2 2,6-dichloro-1-methylsulfonyloxymethyl-3-[N-methyl-N-(phthalimidoacetyl)amino]benzene 
• 167837-48-1 N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide 

Downstream Products

• 179624-26-1 ethyl 5-[(1E)-3-({2-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate 
• 179624-71-6 5-[(1E)-3-({2-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N-methyl-2-pyridinecarboxamide 
• 179624-67-0 5-[(1E)-3-({2-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylic acid 

Relevant articles and documents

A New Series of Highly Potent Non-Peptide Bradykinin B2 Receptor Antagonists Incorporating the 4-Heteroarylquinoline Framework. Improvement of Aqueous Solubility and New Insights into Species Difference

Introduction of nitrogen-containing heteroaromatic groups at the 4-position of the quinoline moiety of our non-peptide B2 receptor antagonists resulted in enhancing binding affinities for the human B 2 receptor and reducing binding affinities for the guinea pig one, providing new structural insights into species difference. A CoMFA study focused on the diversity of the quinoline moiety afforded correlative and predictive QSAR models of binding for the human B2 receptor but not for the guinea pig one. A series of 4-(1-imidazolyl)quinoline derivatives could be dissolved in a 5% aqueous solution of citric acid up to a concentration of 10 mg/mL. A representative compound 48a inhibited the specific binding of [ 3H]BK to the cloned human B2 receptor expressed in Chinese hamster ovary cells with an IC50 value of 0.26 nM and significantly inhibited BK-induced bronchoconstriction in guinea pigs even at 1 μg/kg by intravenous administration.

Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists

This invention relates to a compound of the formula: STR1 wherein Z is a group of the formula: STR2 in which X1 is N or C--R1, X2 is N or C--R9, X3 is N or C--R2, R1 is lower alk