17966-65-3

Upstream product

• 816-66-0 4-methyl-2-oxopentanoic acid 
• 65415-02-3 Phac-DL-Ala-NH₂ 
• 103-80-0 phenylacetyl chloride 
• 718-07-0 N-(Phenylacetyl)-L-alanine 
• 302-72-7 rac-Ala-OH 

Downstream Products

• 41109-05-1 N-Phenylacetyl alanine methyl ester 
• 58482-85-2 2-benzyl-4-methyl-4H-oxazolin-5-one 
• 859800-39-8 (+/-)-β,β-diethoxy-α-(2-phenyl-acetylamino)-isobutyric acid 
• 143947-57-3 3-(N-Phenylacetylamino)-4-(4-oxobenzopyran-3-yl)-3-methyl-N-p-tolylazetidin-2-one 
• 62191-01-9 3-(2-benzyl-4-methyl-5-oxo-4,5-dihydro-oxazol-4-yl)-2-isothiocyanato-3-methyl-butyric acid ethyl ester 
• 62190-97-0 2,4-dibenzyl-4-methyl-4H-oxazol-5-one 
• 145728-52-5 1-(N-phenylacetylamino)ethylphosphonic acid dimethyl ester 
• 145728-55-8 (L,D)-1-(N-phenylacetylamino)ethylphosphinic acid 
• 81069-92-3 (L,D)-1-(N-phenylacetylamino)ethylphosphonic acid 
• 130325-37-0 (S)-1-(N-phenylacetylamino)ethylphosphonic acid 
• 64562-97-6 C₁₂H₁₄ClNO₃ 

Relevant academic research and scientific papers

Racemization method of chiral N-phenylacetyl amino acid and derivatives thereof

The invention belongs to the field of amino acid racemization, and in particular discloses a racemization method of chiral N-phenylacetyl amino acid and derivatives thereof. The method comprises the following steps: heating phenylacetic acid up to 160-180

Penicillin G acylase-mediated kinetic resolution of racemic 1-(N-acylamino)alkylphosphonic and 1-(N-acylamino)alkylphosphinic acids and their esters

Extensive studies on the penicillin G acylase-mediated kinetic resolution of N-acylated 1-aminoalkylphosphonic and 1-aminoalkylphosphinic acids as well as their esters were carried out to recognise the relationships between the substrate structure, reacti

Regioselective synthesis of tetrasubstituted pyrroles by 1,3-dipolar cycloaddition and spontaneous decarboxylation

We developed a novel regioselective synthesis of tetrasubstituted pyrroles via the classic 1,3-dipolar cycloaddition of α,β-unsaturated benzofuran-3(2H)-one and azlactones (1) followed by spontaneous decarboxylation. The complete regiochemical control of tetrasubstituted pyrroles was confirmed by the orthogonal synthesis of complementary regioisomers (7a and 7b) simply by using different azlactones (1a and 1b, respectively).

Structure-Activity Relationships in the Esterase-catalysed Hydrolysis and Transesterification of Esters and Lactones

The Broensted exponents for the alkaline hydrolysis of alkyl esters are 1.3 and 0.4 for substitution in the acyl and alcohol portions, respectively, which is indicative of a transition state which resembles the anionic tetrahedral intermediate with a localised negative charge.By contrast, the rate of the pig liver esterase (PLE)-catalysed hydrolysis shows little dependence upon the electron-withdrawing power of substituents.The values of kcat are independent of the pKa of the leaving group alcohol suggesting rate-limiting deacylation.There is a small steric effect of α-substitution in both the alcohol and carboxylic acid residues for the enzyme-catalysed reactions but the enzyme rate enhancement factor remains high for most esters.There is no substantial ee observed for the hydrolysis of racemic esters although the kinetic data can be used for determining the regioselective hydrolysis of diesters.Unsubstituted lactones are poor substrates for PLE but derivatives with hydrophobic substituents show kcat/Km values similar to those for acyclic esters.Dihydrocoumarin undergoes transesterification catalysed by PLE, kcat increases with increasing alcohol concentration indicative of rate-limiting deacylation.There is enantioselectivity in the PLE-catalysed hydrolysis of some racemic lactones but little or none in the transesterification of racemic alcohols with dihydrocoumarin.

Composition containing a penem or carbapenem antibiotic and the use of the same

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.

Composition containing a penem or carbapenem antibiotic

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.

1-Azadienes in Heterocyclic Synthesis. Reaction of 1-N-Alkyl-1-azapenta-1,3-dienes with Mesoionic Oxazolones

1-N-Alkyl-1-azapenta-1,3-dienes 2 smoothly reacted with various mesoionic oxazolones 1 to afford 3,4-dihydro-2-pyridones 3 in excellent yields and there is no evidence for the formation of any products arising from the cycloaddition on the carbon-carbon double bond or on the azomethine function.