179678-24-1

Basic information

• Product Name: 2-acetyl-6-methoxy-benzoic acid
• Synonyms: 2-acetyl-6-methoxy-benzoic acid
• CAS NO: 179678-24-1
• Molecular Weight: 194.187
• Mol File: 179678-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-acetyl-6-methoxy-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-6-methoxy-benzoic acid(179678-24-1)
• EPA Substance Registry System: 2-acetyl-6-methoxy-benzoic acid(179678-24-1)

Safety Data

• Hazardous Substances Data: 179678-24-1(Hazardous Substances Data)

Upstream product

• 4938-06-1 7-Methoxy-3-methylphthalide 
• 99184-73-3 2-acetyl-6-methoxy-benzonitrile 
• 85865-57-2 2-(Methoxycarbonyl)-3-methoxyacetophenone 

Downstream Products

• 875245-99-1 2-acetyl-3-chloro-6-methoxy-benzoic acid methyl ester 
• 136192-85-3 methyl 1-hydroxy-6-acetylbenzoate 
• 85865-57-2 2-(Methoxycarbonyl)-3-methoxyacetophenone 

Relevant articles and documents

Studies of the New Herbicide KIH-6127. Part I. Novel Synthesis of Methyl 6-Acetylsalicylate as a Key Synthetic Intermediate for the Preparation of 6-Acetyl Pyrimidin-2-yl Salicylates and Analogues

A novel synthesis of methyl 6-acetylsalicylate as a key synthetic intermediate for methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-[1-(methoxyimino)ethyl]benzoate (KIH-6127) was studied, and directed at 6-substituted pyrimidin-2-yl salicylate herbicides and their analogues. Three synthetic approaches were successful: a modification of the Sandmeyer reaction of 6-acetylanthranilate (Method A), a direct ring-opening reaction of 3-methylphthalide using potassium permanganate, and magnesium nitrate (Method B), and a regioselective ortholithiation of the protected 3-hydroxyacetophenone (Method C). These methods were applicable for the synthesis of various 6-acyl salicylates.