17969-44-7

Upstream product

• 17969-48-1 [4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetonitrile 
• 17969-12-9 ethyl 2-(4-(4-chlorophenyl)thiazol-2-yl)acetate 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 679802-69-8 2-(4-(4-chlorophenyl)thiazol-2-yl)-N,N-dimethylacetamide 
• 1403884-17-2 2-bromo-2-(4-(4-chlorophenyl)thiazol-2-yl)-N,N-dimethylacetamide 
• 1403883-91-9 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide 

Relevant academic research and scientific papers

MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER

Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

AROMATIC AMIDES AND USES THEREOF

The present invention provides compounds of Formula (I): and salts, racemates, isomers, diastereoisomers, enantiomers, hydrates, solvates, N-oxides, pharmaceutically acceptable derivatives or prodrugs thereof. Also provided the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.