179744-33-3

Upstream product

• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 150109-60-7 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-fluoro-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-1H-pyrimidine-2,4-dione 
• 129816-30-4 5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine 
• 40224-39-3 N-tert-butyloxycarbonyl-L-valine chloromethyl ester 
• 103782-15-6 2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine 
• 459-46-1 4-Fluorobenzyl bromide 

Relevant academic research and scientific papers

Synthesis and biological activity of O-alkyl-3-N-aminoacyloxymethyl-5- fluoro-2'-deoxyuridine derivatives

In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.