179749-20-3

Upstream product

• 94089-45-9 3-{(R)-1-Methyl-2-[(E)-(S)-1-phenyl-ethylimino]-cyclohexyl}-propionic acid methyl ester 
• 179915-19-6 (E)-3-((R)-1-Methyl-2-oxo-cyclohexyl)-acrylic acid methyl ester 
• 583-60-8 2-Methylcyclohexanone 
• 123522-68-9 methyl (1'R)-3-<2'-(ethylenedioxy)-1'-methylcyclohexyl>prop-2-enoate 
• 123522-75-8 methyl (R)-3-(6-methyl-1,4-dioxaspiro[4.5]decan-6-yl)propanoate 
• 193468-09-6 [2-Methyl-cyclohex-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 
• 53068-89-6 (R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone 
• 179749-19-0 (R)-2-Methyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexanone 
• 74-88-4 methyl iodide 
• 179749-18-9 (R)-6-Methyl-6-((E)-4-methyl-penta-1,3-dienyl)-1,4-dioxa-spiro[4.5]decane 
• 179749-17-8 (E)-3-((R)-6-Methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-prop-2-en-1-ol 
• 179749-14-5 (E)-3-((R)-6-Methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-propenal 

Downstream Products

• 179915-27-6 2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol 
• 179749-23-6 2-[(1R,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol 

Relevant academic research and scientific papers

Total synthesis and absolute configuration of riccardiphenols A and B, isolated from the Liverwort Riccardia crassa

The title compounds were synthesized as optically active forms using chiral Michael addition of the imine, prepared from 2-methylcyclohexanone and (S)-(-)-phenylethylamine, to methyl propiolate. The etherification of the intermediate triol was accomplished by TsOH-catalyzed cyclization. The absolute configurations of the natural products, riccardiphenols A and B, were established as 1 and 2, respectively.