17976-32-8

Basic information

• Product Name: 2,5(10)-ESTRADIEN-3-OL-17-ONE 3-METHYL ETHER
• Synonyms: 2,5(10)-ESTRADIEN-3-OL-17-ONE 3-METHYL ETHER;3-METHOXYESTRA-2,5(10)-DIEN-17-ONE;Einecs 241-893-9;(8R,9S,13S,14S)-3-methoxy-13-methyl-4,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-one
• CAS NO: 17976-32-8
• Molecular Formula: C₁₉H₂₆O₂
• Molecular Weight: 286.41
• EINECS: 241-893-9
• Mol File: 17976-32-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 131-133 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• Boiling Point: 435.7 °C at 760 mmHg
• Flash Point: 187.1 °C
• Appearance: /
• Density: 1.11 g/cm³
• Vapor Pressure: 8.56E-08mmHg at 25°C
• Refractive Index: 1.555
• Water Solubility: 3mg/L at 25℃
• CAS DataBase Reference: 2,5(10)-ESTRADIEN-3-OL-17-ONE 3-METHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5(10)-ESTRADIEN-3-OL-17-ONE 3-METHYL ETHER(17976-32-8)
• EPA Substance Registry System: 2,5(10)-ESTRADIEN-3-OL-17-ONE 3-METHYL ETHER(17976-32-8)

Safety Data

• Hazardous Substances Data: 17976-32-8(Hazardous Substances Data)

Usage

Uses

3-Methoxyestra-2,5(10)-dien-17-one is structurally related to 3-O-Methyl Estrone (M304710); an estrogenic hormone.

InChI:InChI=1/C19H26O2/c1-19-10-9-15-14-6-4-13(21-2)11-12(14)3-5-16(15)17(19)7-8-18(19)20/h4,15-17H,3,5-11H2,1-2H3

Upstream product

• 1091-93-6 (+/-)-3-Methoxy-8α-estra-2,5(10)-dien-17β-ol 
• 1035-77-4 rac-3-methoxy-(8α)-estra-1,3,5(10)-trien-17β-ol 
• 111-87-5 octanol 
• 1255910-17-8 3,17,17-trimethoxy-estra-2,5⁽¹⁰⁾-diene 
• 75863-04-6 3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion 
• 1091-93-6 3-methoxy-17-hydroxyestra-2,5⁽¹⁰⁾-diene 

Downstream Products

• 3962-66-1 estra-5⁽¹⁰⁾-en-3,17-dione 
• 2529-46-6 17-hydroxy-22-methyl-19,21,24-trinor-17βH-chola-4,22-dien-3-one 
• 7359-79-7 17α-Propinyl-19-nortestosteron 
• 68-22-4 norethisterone 
• 51-98-9 norethisterone acetate 
• 2205-78-9 3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne 
• 2137-18-0 17-alpha-Hydroxy-19-norprogesterone 
• 1624-62-0 estrone 3-methyl ether 
• 7358-46-5 17alpha-Allylnandrolone 

Relevant articles and documents

METHOD FOR SYNTHESIS OF DIENOGEST FROM ESTRONE-3-METHYLETHER

A method for the synthesis of dienogest from 3-methoxy-estra-1,3,5-trien-17-one includes the steps of a) reacting 3-methoxy-estra-1,3,5-trien-17-one with alcohol in the presence of an acid in an organic solvent to form 3-methoxy-17,17-dialkoxy-estra-1,3,5

Total-synthesis of (-)-norgestrel

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Synthesis of 13-alkyl-gon-4-ones

The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.