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Usage

Uses

Used in Pharmaceutical Industry:
Flurbiprofen IMpurity B is used as a reference compound for quality control and assurance in the production of Flurbiprofen. It helps in monitoring the purity and safety of the final product, ensuring that the therapeutic benefits of Flurbiprofen are not compromised by the presence of impurities.
Additionally, understanding the properties and effects of Flurbiprofen IMpurity B can aid in the development of methods to reduce or eliminate its presence in the final product, thereby improving the overall efficacy and safety of Flurbiprofen as an anti-inflammatory and analgesic medication.

Relevant academic research and scientific papers

Preparation method of high-purity flurbiprofen known impurities

The invention discloses a preparation method of high-purity flurbiprofen known impurities B. The preparation method comprises the following steps: enabling a tetrahydrofuran solution of 4-bromine-2-fluorobiphenyl as a starting material to perform Grignard reaction with magnesium, acidifying after coupled docking with side chain 2-bromo-2,3-sodium dimethyl succinate, preparing crude products of flurbiprofen impurities and performing re-crystallization on the high-purity flurbiprofen known impurities B, namely 2-(2-fluoro-4-biphenyl)-2,3-dimethylidene succinic acids. The preparation method disclosed by the invention is simple and convenient to operate, short in reaction time, high in product purity, high in yield and suitable for industrial production. The synthesized impurities B can be used for the qualitative and quantitative analysis on the impurities, so that the drug use safety of flurbiprofen is improved.