1797983-09-5
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Basic information
- Product Name: GSK-J4 Hydrochloride
- Synonyms: GSK-J4 Hydrochloride;TYXWLTBYINKVNT-UHFFFAOYSA-N;Ethyl N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alaninate hydrochloride
- CAS NO:1797983-09-5
- Molecular Formula: C24H28ClN5O2
- Molecular Weight: 453.96442
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1797983-09-5.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
- Solubility: N/A
- CAS DataBase Reference: GSK-J4 Hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: GSK-J4 Hydrochloride(1797983-09-5)
- EPA Substance Registry System: GSK-J4 Hydrochloride(1797983-09-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1797983-09-5(Hazardous Substances Data)
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1797983-09-5 Usage
Description
GSK-J4 Hydrochloride, an ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1, is a compound that plays a significant role in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. It acts as a prodrug, being rapidly hydrolyzed in cells to the otherwise cell impermeable GSK-J1, which is a potent inhibitor of the histone H3 lysine 27 (H3K27) demethylase JMJD3/UTX. This inhibition blocks the demethylation of histone H3K27, thereby affecting various cellular processes.Uses
Used in Pharmaceutical Industry:GSK-J4 Hydrochloride is used as a histone demethylase JMJD3/UTX inhibitor for its ability to block the demethylation of histone H3K27. This makes it a potential therapeutic agent in the treatment of various diseases, including cancer, by modulating the epigenetic landscape of cells.
Used in Inflammatory Response Regulation:
GSK-J4 Hydrochloride is used as an anti-inflammatory agent for its ability to reduce LPS-induced proinflammatory cytokine production in human primary macrophages, most notably including that of TNFα (IC50 = 9 μM). This suggests its potential use in treating inflammatory conditions and diseases.
Used in Cancer Research:
GSK-J4 Hydrochloride is used as a research tool for studying the role of histone demethylation in cancer development and progression. Its ability to inhibit JMJD3/UTX demethylase activity can provide insights into the epigenetic mechanisms underlying cancer and may lead to the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 1797983-09-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,9,7,9,8 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.Calculate Digit Verification of CAS Registry Number 1797983-09:
(9*1)+(8*7)+(7*9)+(6*7)+(5*9)+(4*8)+(3*3)+(2*0)+(1*9)=265
265 % 10 = 5
So 1797983-09-5 is a valid CAS Registry Number.
1797983-09-5Upstream product
1797983-09-5Downstream Products
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GSK-J4 Hydrochloride
