17983-32-3Relevant academic research and scientific papers
Synthesis of Silacyclohexanones from Divinylsilanes and Allylamines by a Rh-Catalyzed Cyclization
Guo, Jiawei,Liu, Song,Pang, Qinjiao,Zhang, Hongyun,Gao, Lu,Chen, Li,Song, Zhenlei
supporting information, p. 726 - 730 (2022/01/20)
An efficient synthesis of silacyclohexanones bearing a variety of silyl substituents has been developed by a [Rh(coe)2Cl]2/PCy3-catalyzed cyclization of divinylsilanes with Jun’s allylamine. The silacyclohexanones can be o
Catalytic Asymmetric Homologation of 4-Substituted Cyclohexanones with CF3CHN2: Enantioselective Synthesis of α-Trifluoromethyl Cycloheptanones
Li, Shu-Sen,Sun, Shuo,Wang, Jianbo
supporting information, (2021/12/27)
Introduction of the trifluoromethyl group (CF3) into organic molecules in an enantioselective manner has attracted significant attention, but still remains a challenging problem. We herein report a catalytic asymmetric trifluoromethylation of cyclic ketones via a ScIII/chiral bisoxazoline-catalyzed homologation reaction by employing 2,2,2-trifluorodiazoethane (CF3CHN2) as the CF3 source. This desymmetrization process is highly efficient and generates two chiral centers with excellent diastereoselectivity and enantioselectivity, affording chiral α-trifluoromethyl cyclic ketones in a straightforward manner.
[...] piperidine derivative and its preparation method and use thereof (by machine translation)
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Paragraph 0210; 0229-0231, (2018/08/28)
The present invention provides a novel structure sila piperidine derivative or a pharmaceutically acceptable salt or solvate thereof, wherein the structure general formula is represented by a formula (I). The present invention further provides a drug composition containing a pharmaceutically effective amount of the sila piperidine derivative or the pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable excipient or additive. The present invention further discloses a synthesis method for the sila piperidine derivative, wherein dichloro-substituted silane is adopted as a starting raw material, and multi-step reactions are integrated and performed in one pot to obtain the high purity pharmaceutical intermediate for preparing the camptothecin sila derivative, wherein the synthesis route is short, the reaction environments, especially the temperature, the pressure and the like, are safe and controlled, and the characteristic of green environmental protection is provided. In addition, the preparation raw materials have the wide sources and are easy to obtain, the preparation method is simple and is easy to operate, the reaction conditions are mild, the synthesized product yield is high, and great industrial application values are provided.
TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
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Page/Page column 18, (2012/06/16)
The invention relates to compounds of formula (I), where: A is a bond, an oxygen, or an —CH2— group; Ar1 is a phenyl or heteroaryl group; Ar2 is a phenyl, heteroaryl, or heterocycloalkyl group; R1a,b,c and R2a,b,c are hydrogen or halogen, or an alkyl, cycloalkyl, or lkyl-cycloalkyl group optionally, substituted by one or more halogen atoms, or a —OR5 (hydroxy or alkoxy), hydroxy-alkyl, alkoxy-alkyl, alkoxy-alkoxy, halogenoalkyl, —O-halogenoalkyl, oxo, —CO-alkyl, —CO-alkyl-NR6R7, —CO-halogenoalkyl, —COOR5, alkyl-COOR5, —O-alkyl-COOR5, —SO2-alkyl, —SO2-cycloalkyl, —SO2-alkyl-cycloalkyl, —SO2-alkyl-OR5, —SO2-alkyl-COOR5, —SO2-alkyl-NR6R7, —SO2-halogenoalkyl, alkyl-SO2-alkyl, —SO2—NR6R7, —SO2-alkyl-O-alkyl-OR5, —CONR6R7, -alkyl-CONR6R7, or -alkyl-NR6R7 group, or further R1a, R1b, and R1c are bonded to R2a, R2b, R2c, respectively, and to the carbon atom having same, and are -alkyl-O—; R3 is a hydrogen atom or an alkyl group; R4 is a hydrogen or halogen atom or a cyano, —OR5, hydroxyalkyl, —COOR5, —NR6R7, ONR6R7, —SO2-alkyl, SO2—NR6R7, —NR6—COOR5, —NR6—COR5, or —CO—NR6-alkyl-OR5 group; R5, R6, and R7 are a hydrogen, or an alkyl or alkyl-phenyl group; and R8 is an alkyl, alkyl-Si(alkyl)3, —SO2-alkyl-Si(alkyl)3, phenyl, alkoxy-imino group, or alkyl-cycloalkyl group optionally substituted by one or more halogen atoms or one or more hydroxyl or hydroxyl-alkyl groups; or R8 and R9, together with the carbon atoms to which they are bonded, form a cycloalkyl group optionally substituted by one or more halogen atoms or one or more carboxy groups; and R9 is a hydrogen atom or an alkyl group; with the proviso that, when R8 is an alkyl group, it is bonded onto the Ar2 silicon atom. The invention also relates to a method for preparing same and to the therapeutic use thereof.
CHEMISTRY OF ORGANOSILICON COMPOUNDS. CXXIII. NEW PHOTOCHEMICAL AND THERMAL DEGRADATION REACTIONS OF VINYLDISILANES TO VINYLSILANES THROUGH (η3-1-SILAPROPENYL)TRICARBONYLIRON COMPLEXES
Sakurai, Hideki,Kamiyama, Yoshiyasu,Nakadaira, Yasuhiro
, p. 13 - 30 (2007/10/02)
Vinyldisilanes (II) of the type R1CH=CR2SiMe2SiMe3 (a, R1 = Ph, R2 = H; b, R1 = H, R2 = Me; c, R1 = R2 = H) and (R1CH = CHSiMeR3-)2 (d, R1 = Ph, R3 = Me; e, R1 = H, R3 = Ph) undergo a novel degradation reaction to give the corresponding vinylsilanes, R1CH = CR2SiMe3 and (R1CH=CH)2SiMeR3, respectively, under photochemical or thermal conditions in the presence of a stoichiometric amount of pentacarbonyliron.Two α-styryldisilanes (IIf, CH2=CPhSiMe2SiMe3 and IIg, 2) undergo similar degradation reactions, but gave β-styryl- silanes.In the presence of additional benzophenone, IIb, IIc, and IIf gave (E)-Me3SiCH=CRSiMe2OCHPh2 (b, R = Me; c, R = H; f, R = Ph) under either photochemical or thermal conditions, but IIa gave under photochemical, or Ph2CHSiMe3 under thermal conditions as main product.Mechanisms involving η3-1-silapropenyltricarbonyliron intermediates are proposed, and indeed separately prepared (η3-1-silapropenyl)(trimethylsilyl)tricarbonyliron gave the same products under similar conditions.
