179863-69-5

Basic information

• Product Name: tert-Butyl (2S,4R)-tert-butoxycarbonylamino-5-hydroxy-4-tert-butyldiphenylsilyloxymethyl[5,5-2H₂]pentanoate
• CAS NO: 179863-69-5
• Molecular Weight: 559.787
• Mol File: 179863-69-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-Butyl (2S,4R)-tert-butoxycarbonylamino-5-hydroxy-4-tert-butyldiphenylsilyloxymethyl[5,5-2H₂]pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (2S,4R)-tert-butoxycarbonylamino-5-hydroxy-4-tert-butyldiphenylsilyloxymethyl[5,5-2H₂]pentanoate(179863-69-5)
• EPA Substance Registry System: tert-Butyl (2S,4R)-tert-butoxycarbonylamino-5-hydroxy-4-tert-butyldiphenylsilyloxymethyl[5,5-2H₂]pentanoate(179863-69-5)

Safety Data

• Hazardous Substances Data: 179863-69-5(Hazardous Substances Data)

Upstream product

• 418812-75-6 (S)-4-Hydroxymethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester 
• 163190-50-9 tert-Butyl (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylglutamic acid 
• 163190-48-5 tert-Butyl (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylpyroglutamate 
• 163190-46-3 tert-Butyl (2S)-N-tert-butoxycarbonyl-4-methylideneprolinate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 84348-38-9 (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid 

Relevant articles and documents

Synthesis of (2S,4S)- And (2S,4R)-5,5′-dihydroxy[5,5-2H2]leucine by two independent routes

In studies directed at discovering the absolute stereochemistry of the reaction catalysed by the enzyme glutamate γ-carboxylase, two independent stereoselective syntheses of (2S,4S)-5,5′-dihydroxy[5,5- 2H2]-leucine 4a and its (2S,4R)-diastereoisomer 4b have been developed. The first synthesis uses (2S)-pyroglutamic acid as starting material and provides (2S,4S)-5,5′-dihydroxy[5,5-2H2]leucine 4a, while the second starts with (2S,4R)-4-hydroxyproline and provides (2S,4R)-5,5′-dihydroxy[5,5-2H2]leucine 4b.