179901-13-4

Upstream product

• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 10203-58-4 (2-methylpropyl)-propanedioic acid, diethyl ester 
• 2985-36-6 2-ethoxycarbonyl-4-methylpentanoic acid 
• 622-30-0 N-benzyl hydroxylalmine 

Downstream Products

• 1026475-72-8 4-{2-[(S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-4-phenyl-butyrylamino]-ethyl}-benzoic acid methyl ester 
• 202653-16-5 (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide 
• 1027979-35-6 N-Benzyloxy-N'-{(S)-1-[2-(4-hydroxy-phenyl)-ethylcarbamoyl]-3-phenyl-propyl}-2-isobutyl-malonamide 
• 202652-97-9 4-{2-[(S)-2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-4-phenyl-butyrylamino]-ethyl}-benzoic acid methyl ester 
• 1026034-38-7 N-(2-Benzylcarbamoyl-phenyl)-N'-benzyloxy-2-isobutyl-malonamide 
• 1026379-29-2 N-((S)-1-Benzylcarbamoyl-2-phenyl-ethyl)-N'-benzyloxy-2-isobutyl-malonamide 
• 1026291-38-2 (S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide 
• 71431-58-8 N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide 

Relevant academic research and scientific papers

DUAL-ACTING ANTIHYPERTENSIVE AGENTS

The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhib

Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8)

For most of the known synthetic inhibitors of matrix metalloproteinases (MMPs), a substrate-like binding mode was postulated on the basis of X-ray crystallographic structures of MMP/ inhibitor complexes. Conversely, the malonic acid-based inhibitor (2R, S

Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle

Hydroxamic acids 6a-h, derived from malonyl amino acids, and 25a-d, derived from succinyl amino acids, were synthesized as inhibitors of human bronchiolar smooth muscle endothelin-converting enzyme (HBSM ECE). Several unexpected side reactions were discov