179901-29-2Relevant academic research and scientific papers
Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8)
Von Reedern, Erich Graf,Grams, Frank,Brandstetter, Hans,Moroder, Luis
, p. 339 - 345 (1998)
For most of the known synthetic inhibitors of matrix metalloproteinases (MMPs), a substrate-like binding mode was postulated on the basis of X-ray crystallographic structures of MMP/ inhibitor complexes. Conversely, the malonic acid-based inhibitor (2R, S
