179925-35-0

Upstream product

• 100-69-6 2-vinylpyridine 
• 93130-36-0 3'-acetyl-5'-O-DMT-N²-isobutyryl-2'-deoxyguanosine 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 68892-42-2 N-isobutyryl-2'-deoxyguanosine 

Downstream Products

• 179925-36-1 5'-O-DMT-N²-isobutyryl-O⁶-(2-ethylpyridyl)-2'-deoxyguanosine 

Relevant academic research and scientific papers

2-Vinylpyridine : A novel reagent for O6 protection of 2′-deoxyguanosine

2-Vinylpyridine has been successfully used for the protection of O6/N-1-lactam function in N2, 3′, 5′-protected 2′-deoxyguanosine followed by phosphonylation at 3′-end to yield the fully protected monomer for oligonucleotide synthesis, It is easier to introduce this group and then deprotect under milder conditions using 1, 8-diazabicyclo[5.4.0]undec-7-ene in anhyd. pyridine. Two oligonucleotides, viz. a hexamer, d(ACTGGC) and an octamer, d(GCCACTGT) have been synthesised in fairly good yields using this monomer on solid-phase without any side reactions.