179927-57-2Relevant academic research and scientific papers
An efficient synthesis of C20-C25 building blocks for calyculin A
Hamada, Yasumasa,Yokokawa, Fumiaki,Kabeya, Mototsugu,Hatano, Keiichiro,Kurono, Yukihisa,Shioiri, Takayuki
, p. 8297 - 8306 (2007/10/03)
The C20-C25 building blocks 2 and 3a for calyculin A, a protein phosphatase inhibitor, have been efficiently prepared from L-malic acid utilizing the Grignard reaction of the Weinreb amides 8 and 14, followed by stereoselective reduction of the ketones 9 and 15, respectively, as the key steps. Copyright
