17993-96-3Relevant academic research and scientific papers
Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation
Ho, Yee Ann,Leiendecker, Matthias,Liu, Xiangqian,Wang, Chengming,Alandini, Nurtalya,Rueping, Magnus
supporting information, p. 5644 - 5647 (2018/09/12)
A nickel-catalyzed cross coupling of aryl fluorides via C-F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult to access scaffolds in good yields.
Palladium-catalyzed C(sp3)-C(sp2) cross-coupling of homoleptic rare-earth metal trialkyl complexes with aryl bromides: Efficient synthesis of functionalized benzyltrimethylsilanes
Cai, Guilong,Huang, Yingda,Du, Tingting,Zhang, Shaowen,Yao, Bo,Li, Xiaofang
supporting information, p. 5425 - 5427 (2016/05/09)
The first C(sp3)-C(sp2) cross-coupling of rare-earth metal alkyl complexes with aryl bromides has been developed. This reaction was conducted at low catalyst loading (0.5 mol%) and exhibited a broad substrate scope, thus providing a facile method for the synthesis of benzyltrimethylsilanes with diverse functional groups.
Palladium-catalyzed C(sp 3)-C(sp 2) cross-coupling of (trimethylsilyl)methyllithium with (hetero)aryl halides
Heijnen, Dorus,Hornillos, Valentín,Corbet, Brian P.,Giannerini, Massimo,Feringa, Ben L.
supporting information, p. 2262 - 2265 (2015/05/13)
The palladium-catalyzed direct cross-coupling of a range of organic chlorides and bromides with the bifunctional C(sp3)-(trimethylsilyl)methyllithium reagent is reported. The use of Pd-PEPPSI-IPent as the catalyst allows for the preparation of structurally diverse and synthetically versatile benzyl- and allylsilanes in high yields under mild conditions (room temperature) with short reaction times.
Metal-catalyzed dealkoxylative Caryl-C sp 3 cross-coupling - Replacement of aromatic methoxy groups of aryl ethers by employing a functionalized nucleophile
Leiendecker, Matthias,Hsiao, Chien-Chi,Guo, Lin,Alandini, Nurtalya,Rueping, Magnus
supporting information, p. 12912 - 12915 (2016/02/18)
The direct replacement of aromatic methoxy groups with activated carbon nucleophiles would give rise to novel synthetic pathways for targeted and diversity-oriented syntheses. We demonstrate here that this transformation can be achieved in a one-step reac
Room temperature observation of p-xylylenes by 1H NMR and evidence for diradical intermediates in their oligomerization
Trahanovsky, Walter S.,Lorimor, Steven P.
, p. 1784 - 1794 (2007/10/03)
p-Quinodimethanes (p-QDMs) are reactive molecules that have been invoked as transient intermediates in a number of reactions. Dilute solutions of benzene-based p-QDMs, p-xylylene (1), α-methyl-p-xylylene (10), and 2,5-dimethyl-p-xylylene (11) can be prepared by fluoride-induced elimination of trimethylsilyl acetate from the appropriate precursor. It has been found that these solutions are stable enough to allow these reactive p-QDMs to be observed by 1H NMR spectroscopy at room temperature. For the first time, the 13C NMR spectrum of p-QDM 1 was observed. After several hours at room temperature, these p-QDMs form dimers, trimers, and insoluble oligomers. Formation of trimers provides evidence that p-QDMs 1, 10, and 11 dimerize by a stepwise mechanism involving dimeric diradicals as intermediates.
Methylbenzene Cation Radical α-Fragmentation Selectivities Revealed in SET-Photoadditions of p-Xylene Derivatives to 1,4-Dicyanonaphthalene
d'Alessandro, Nicola,Albini, Angelo,Mariano, Patrick S.
, p. 937 - 942 (2007/10/02)
SET-promoted photoreactions of selected p-xylene derivatives, including p-xylene (3a), p-phenylenediacetic acid (3b), p-bisbenzene (3c), p-toluene (3d), p-tolylacetic acid (3e), and p-(trimethylsilyl)methyl
