179930-56-4

Upstream product

• 109-77-3 malononitrile 

Downstream Products

• 179930-46-2 7-(4-Amino-phenyl)-5-(3,4-dimethoxy-phenyl)-3-(2-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 179930-44-0 7-(4-Amino-phenyl)-5-(3,4-dimethoxy-phenyl)-3-(4-ethoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 179930-47-3 7-(4-Amino-phenyl)-5-(3,4-dimethoxy-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 179930-45-1 7-(4-Amino-phenyl)-5-(3,4-dimethoxy-phenyl)-2-thioxo-3-p-tolyl-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 179930-58-6 2-Amino-6-(4-amino-phenyl)-4-(3,4-dimethoxy-phenyl)-nicotinamide 

Relevant academic research and scientific papers

Synthesis of novel thioxoderivatives of pyrido[2,3-d]pyrimidines and their nucleosides as possible anticancer agents

Synthesis of some 2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-4(1H)-ones and corresponding nucleosides viz. 2-mioxo-3,5,7-trisubstiwted-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl) pyrido[2,3-d]-pyrimidine-4 (1H)-ones is reported. The results of antimicrobial activities are also reported. The structures of the compounds have been established by elemental, IR and NMR analyses.

Synthesis of some new pyrimidine bases as precursors of potential anticancer nucleosides

3,5,7-Trisubstituted-pyridopyrimidine-2,4(1H,3H)-diones (4) have been synthesized from the reaction of 2-amino-3-cyano-4,6-diarylpyridines (2) with arylisocyanates in dioxan-pyridine.Compounds 4 have also been prepared by the hydrolysis of 2 with alc.KOH to give 2-amino-3-carboxamido-4,6-disubstituted pyridines (3) which on refluxing with arylisocyanate in diphenyl ether afford 4.They are characterised by elemental analyses and IR and 1H NMR spectral data.They have been tested for antibacterial and antifungal activity.