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180-94-9

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180-94-9 Usage

General Description

Piperidone-4-propyleneketal is a chemical compound that belongs to the class of piperidone derivatives. It has the molecular formula C9H15NO and a molecular weight of 141.22 g/mol. Piperidone-4-propyleneketal is a colorless liquid with a mild odor, and it is soluble in organic solvents such as ethanol and ether. This chemical is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of fragrances and flavoring compounds. Its properties make it a valuable intermediate in the manufacturing of various products, and it is important to handle it with proper care due to its potential health and environmental hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 180-94-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,8 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 180-94:
(5*1)+(4*8)+(3*0)+(2*9)+(1*4)=59
59 % 10 = 9
So 180-94-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H15NO2/c1-6-10-8(11-7-1)2-4-9-5-3-8/h9H,1-7H2

180-94-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,5-dioxa-9-azaspiro[5.5]undecane

1.2 Other means of identification

Product number -
Other names 4-Piperidone propylene ketal

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:180-94-9 SDS

180-94-9Relevant articles and documents

Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity

Nyantakyi, Samuel Agyei,Li, Ming,Gopal, Pooja,Zimmerman, Matthew,Dartois, Véronique,Gengenbacher, Martin,Dick, Thomas,Go, Mei-Lin

supporting information, p. 5733 - 5750 (2018/06/20)

The inclusion of an azaspiroketal Mannich base in the membrane targeting antitubercular 6-methoxy-1-n-octyl-1H-indole scaffold resulted in analogs with improved selectivity and submicromolar activity against Mycobacterium tuberculosis H37Rv. The potency enhancing properties of the spiro-fused ring motif was affirmed by SAR and validated in a mouse model of tuberculosis. As expected for membrane inserting agents, the indolyl azaspiroketal Mannich bases perturbed phospholipid vesicles, permeabilized bacterial cells, and induced the mycobacterial cell envelope stress reporter promoter piniBAC. Surprisingly, their membrane disruptive effects did not appear to be associated with bacterial membrane depolarization. This profile was not uniquely associated with azaspiroketal Mannich bases but was characteristic of indolyl Mannich bases as a class. Whereas resistant mycobacteria could not be isolated for a less potent indolyl Mannich base, the more potent azaspiroketal analog displayed low spontaneous resistance mutation frequency of 10-8/CFU. This may indicate involvement of an additional envelope-related target in its mechanism of action.

Synthesis of 5-oxyquinoline derivatives for reversal of multidrug resistance

Dittrich, Torsten,Hanekop, Nils,Infed, Nacera,Schmitt, Lutz,Braun, Manfred

supporting information, p. 1700 - 1704 (2013/01/15)

The inhibition of ABC (ATP binding cassette) transporters is considered a powerful tool to reverse multidrug resistance. Zosuquidar featuring a difluorocyclopropyl-annulated dibenzosuberyl moiety has been found to be an inhibitor of the P-glycoprotein, one of the best-studied multidrug efflux pumps. Twelve 5-oxyisoquinoline derivatives, which are analogues of zosuquidar wherein the dibenzosuberyl-piperazine moiety is replaced by either a diarylaminopiperidine or a piperidone-derived acetal or thioacetal group, have been synthesized as pure enantiomers. Their inhibitory power has been evaluated for the bacterial multidrugresistance ABC transporter LmrCD and fungal Pdr5. Four of the newly synthesized compounds reduced the transport activity to a higher degree than zosuquidar, being up to fourfold more efficient than the lead compound in the case of LmrCD and about two times better for Pdr5.

Quinoline, naphthyridine and pyridobenzoxazine derivatives

-

, (2008/06/13)

Novel antibacterial compounds are disclosed having the formula STR1 as well as pharmaceutically acceptable salts, esters, amide and prodrugs thereof, wherein R1 is selected from the group consisting of (a) lower alkyl, (b) halo(lower alkyl), (c

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