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Usage

Uses

Used in Organic Synthesis:
(Z)-N-(1-chloro-1-(4-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide is used as a reagent in organic synthesis for its ability to contribute to the formation of new chemical entities with potential applications in various industries.
Used in Pharmaceutical Research:
In Pharmaceutical Research, (Z)-N-(1-chloro-1-(4-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide is used as a compound with potential biological activity, which may lead to the development of new drug candidates and therapeutic agents for disease treatment.
Used in Chemical and Biochemical Processes:
(Z)-N-(1-chloro-1-(4-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide is used as an inhibitor, ligand, or catalyst in various chemical and biochemical processes, leveraging its structural features to modulate reactions and interactions.
Further Research:
(Z)-N-(1-chloro-1-(4-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide is a subject of ongoing research to fully understand its properties and potential uses, which may lead to novel applications in different fields.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 449-81-0 4-(4-fluorobenzylidene)-2-phenyloxazol-5(4H)-one 
• 495-69-2 Hippuric Acid 
• 110-89-4 piperidine 
• 449-81-0 (4Z)-2-phenyl-4-[(4-fluorophenyl)methylidene]-1,3-oxazol-5(4H)-one 

Relevant academic research and scientific papers

Synthesis and quantitative structure-activity relationships study for phenylpropenamide derivatives as inhibitors of hepatitis B virus replication

A series of new phenylpropenamide derivatives containing different substituents was synthesized, characterized and evaluated for their anti-hepatitis B virus (HBV) activities. The quantitative structure eactivity relationships (QSAR) of phenylpropenamide compound have been studied. The 2D-QSAR models, based on DFT and multiple linear regression analysis methods, revealed that higher values of total energy (TE) and lower entropy (Sθ) enhanced the anti-HBV activities of the phenylpropenamide molecules. Predictive 3D-QSAR models were established using SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.

Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication

A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure-activity relationships of this series are discussed. (C) 2000 Elsevier Science Ltd.