18002-03-4

Upstream product

• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 4971-77-1 ethyl 2-phenylethanimidoate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 4815-28-5 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 140-29-4 phenylacetonitrile 
• 108-94-1 cyclohexanone 
• 122-78-1 phenylacetaldehyde 
• 103-81-1 Benzeneacetamide 
• 76488-06-7 Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate-hydrochloride 
• 645-54-5 2-phenylthioacetamide 

Downstream Products

• 423128-56-7 2-benzyl-4-(4-methylpiperazin-1-yl)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidine 
• 401511-15-7 2-benzyl-4-[(2-hydroxy)ethyl]amino-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidine 
• 83548-57-6 2-Benzyl-4-chloro-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine 
• 83548-64-5 (2-Benzyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazine 
• 83548-71-4 4-Benzyl-7,8,9,10-tetrahydro-6-thia-1,2,3,3a,5-pentaaza-cyclopenta[c]fluorene 
• 947328-95-2 2-benzyl-4-[(3-hydroxy)propyl]amino-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyrimidine 

Relevant academic research and scientific papers

ZnO-CeO2 nanocomposite: Efficient catalyst for the preparation of thieno[2,3-d]pyrimidin-4(3H)-one derivatives

The Zinc oxide-cerium oxide (ZnO-CeO2) nanocomposite was prepared by a coprecipitation method and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and particle size distribution analysis. The XRD p

Antihelminthic activity of some 2-substituted thieno[2,3-d]pyrimidin-4-ones

Background: One of the successful approaches for rational design of bioactive compounds is the bioisosterism strategy. Thus, the bioisosteric relation of thieno[2,3-d]pyrimidin-4-ones with quinazolines, cytosine and uracil resulted in the generation of co

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds. This journal is the Partner Organisations 2014.

Multistep, microwave assisted, solvent free synthesis and antibacterial activity of 6-substituted-2,3,4-trihydropyrimido[1,2-c]9,10,11,12- tetrahydrobenzo[b]thieno[3,2-e]pyrimidines

A novel, efficient, microwave assisted route for the synthesis of 6-substituted-2,3,4-trihydropyrimido[1,2-c]-9,10,11,12-tetrahydrobenzo[b] thieno[3,2-e]pyrimidines in good yields has been developed. The intermediates, 2-substituted-4-[3-hydroxy(propyl-1-

Microwave-Assisted Synthesis of Novel 5-Substituted-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidines

A novel, facile microwave-assisted route for the synthesis of imidazo[1,2-c]thieno[3,2-e]pyrimidines 4 in quantitative yields is reported. The intermediates 4-chlorothieno[2,3-d]pyrimidines 3 were synthesized under one-pot reaction conditions.

Synthesis of fused pyrimidinones by reaction of aminoarene-carboxamide with esters; Preparation of pyrrolo[2,3-d]-, thieno[2,3-d]-, isoxazolo[5,4-d]- and 1,2,3-triazolo[4,5-d]pyrimidinones, and quinazolones

Several fused pyrimidinones were synthesized by reaction of aminoarenecarboxamide with esters in moderate to good yields. In the presence of sodium ethoxide, treatments of 2-amino-l-phenyl-3-pyrrolecarboxamide(4, 5, and 6), 2-amino-3-thiophenecarboxamide (14), 3-amino-4-isoxazolecarboxamide (10 and 11), 4-amino-1,2,3-triazole-5-carboxamide (16), and o-aminobenzamide (18) with esters (3) such as ethyl formate (3a) and ethyl acetate (3b) led to the corresponding pyrrolo[2,3-d]- (7, 8, and 9), and thieno[2,3-d]pyrimidin-4(3H)-ones (15), isoxazolo[5,4-d]pyrimidin-4(5H)-ones (12 and 13), 1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-ones (17), and 4(3H)-quinazolones (19), respectively.

Synthesis and Biological Activity of Tetrazolothienopyrimidines

4-Hydrazinothienopyrimidines (VI) undergo cyclization with nitrous acid to give tetrazolothienopyrimidines (VII).The latter compounds have been screened for their analgesic and antiinflammatory activities.