180037-06-3Relevant articles and documents
Investigations on the pathway of the fluorescence reaction of a pharmaceutically important 1,3-diamine with 2-benzoylbenzaldehyde
Troschuetz, Reinhard,Heinemann, Oliver
, p. 267 - 269 (1996)
The reaction of 2-benzoylbenzaldehyde (1) with primary diamine 2, generated by rearrangement and hydrolysis of Oxazepam, in CD3OD leads to intensely fluorescing deuterated isoindoloquinazolines 3 and 4. Reduction of ethyl 2-benzoylbenzoate (5) with LiAlD4 followed by oxidation with MnO2 yields 2-benzoyl-benz[D]aldehyde (7). The condensation of 7 with diamine 2 leads to isoindoloquinazoline 12, free of deuterium. On the basis of these experiments a plausible pathway is proposed for the 'fluorescence reaction'.