18006-56-9Relevant articles and documents
Facile cleavage of N-arylsulfonyl bond of N-arylsulfonyl-imidazolidinone with magnesium in methanol
Nadir, Upender K.,Krishna, R. Vijaya
, p. 737 - 739 (2004)
Cleavage of N-arylsulfonyl bond in N-arylsulfonylimidazolidinones is best carried out selectively with magnesium in methanol.
Synthetic method and application of urea compound
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Paragraph 0147-0150, (2019/06/07)
The invention relates to a synthetic method of a urea compound, comprising the following steps: adding substituted oxazolone and sodium acetate into a methanol solution, and adding substituted amine under the stirring condition, reacting and carrying out column chromatography to obtain the urea compound. The defect that dangerous compounds need to be used during existing synthetic process is overcome, and a one-pot method is adopted to replace an existing reaction with low yield. The method of the invention has mild reaction condition, the operation is simple, raw materials are easily available, and the substrate can be converted into various other useful molecules. The compound has strong practicality, and can be applied to synthesis of the pesticide daimuron, dieresis long and the anti-cancer drug Sorafenib. The invention relates to a green and environmentally-friendly unsymmetrical urea compound synthesis method with simple process and low cost.
Spectroscopic kinetic study of the interaction of urethanes with amines
Dzalmukhanova,Lodygina,Komratova,Badamshina
, p. 656 - 661 (2014/01/23)
The exchange reactions of phenyl-N-phenylurethane with amines varying in structure and nature have been investigated in o-dichlorobenzene. In the absence of a catalyst and proton-donating compound, the unimolecular decomposition of phenyl-N-phenylurethane into isocyanate and alcohol takes place at a noticeable rate starting at 250°C. The exchange reactions at 60-80°C proceed as a direct exchange between the urethane and the proton donor and are second-order up to high conversions, practically until the disappearance of the entire urethane. The activation energies and apparent rate constants of the exchange reactions of phenyl-N-phenylurethane with various amines have been determined. The results have been explained in terms of the dependence of kinetic parameters of the reaction on the amine nature, structure, and nucleophilicity, on the steric accessibility of the amino group, and on the molecular organization of the solution. Pleiades Publishing, Ltd., 2013.