180068-03-5Relevant articles and documents
An efficient and stereoselective conversion of lactones to substituted cyclic ethers
Yoda, Hidemi,Mizutani, Masato,Takabe, Kunihiko
, p. 679 - 686 (1998)
A general route to substituted cyclic ethers has been described by using nucleophilic addition of Grignard reagents to lactones in the presence of CeCl3 followed by the Lewis acid-induced deoxygenation of the corresponding hemiketals with Et3SiH. Stereoselective reduction of the 5-membered adducts to the disubstituted tetrahydrofurans has been also investigated.