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5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine] is a chemical compound characterized by the formula C16H17ClN2O. It is a derivative of piperidine, featuring a chlorine atom attached to the 5th carbon of the piperidine ring. 5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine] is distinguished by its spiro[isobenzofuran-1,4'] structure, which is a fusion of a benzene ring with a furan ring, both connected to the piperidine ring. Its unique structure and properties render it a promising candidate for pharmaceutical applications, particularly as a building block in the synthesis of biologically active molecules in medicinal chemistry.

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  • 180160-48-9 Structure
  • Basic information

    1. Product Name: 5-chloro-3H-spiro[isobenzofuran-1,4'-piperidine]
    2. Synonyms: 5-chloro-3H-spiro[isobenzofuran-1,4'-piperidine];5-Chlorospiro[isobenzofuran-1(3H),4'-piperidine]
    3. CAS NO:180160-48-9
    4. Molecular Formula: C12H14ClNO
    5. Molecular Weight: 223.69866
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 180160-48-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 351.5 °C at 760 mmHg
    3. Flash Point: 166.4 °C
    4. Appearance: /
    5. Density: 1.26
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 10.10±0.20(Predicted)
    10. CAS DataBase Reference: 5-chloro-3H-spiro[isobenzofuran-1,4'-piperidine](CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-chloro-3H-spiro[isobenzofuran-1,4'-piperidine](180160-48-9)
    12. EPA Substance Registry System: 5-chloro-3H-spiro[isobenzofuran-1,4'-piperidine](180160-48-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 180160-48-9(Hazardous Substances Data)

180160-48-9 Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine] is utilized as a key intermediate in the synthesis of various biologically active compounds due to its unique structural features. Its presence in the molecular framework can potentially enhance the pharmacological properties of the resulting compounds, making it a valuable component in drug discovery and development processes.
Used in Medicinal Chemistry Research:
As a building block in medicinal chemistry, 5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine] is employed for the design and synthesis of new pharmaceutical agents. Its incorporation into molecular structures can lead to the discovery of novel drugs with improved efficacy, selectivity, and safety profiles for the treatment of various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 180160-48-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,1,6 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 180160-48:
(8*1)+(7*8)+(6*0)+(5*1)+(4*6)+(3*0)+(2*4)+(1*8)=109
109 % 10 = 9
So 180160-48-9 is a valid CAS Registry Number.

180160-48-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chlorospiro[1H-2-benzofuran-3,4'-piperidine]

1.2 Other means of identification

Product number -
Other names 5-chloro-3H-spiro[isobenzofuran-1,4'-piperidine]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:180160-48-9 SDS

180160-48-9Downstream Products

180160-48-9Relevant articles and documents

NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES

-

, (2008/06/13)

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

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