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4-(3-Methoxy-phenyl)-piperidin-4-ol, also known as PMPO, is a synthetic opioid analgesic belonging to the class of piperidines. It possesses both analgesic and sedative properties, acting as a potent and selective agonist at the μ-opioid receptor, which mediates the effects of opioids. PMPO has been studied for its potential use in treating pain and addiction, but it also carries risks of abuse, dependence, respiratory depression, and overdose.
Used in Pharmaceutical Industry:
4-(3-Methoxy-phenyl)-piperidin-4-ol is used as an analgesic agent for the management of moderate to severe pain. Its high affinity for the μ-opioid receptor makes it effective in providing pain relief.
4-(3-Methoxy-phenyl)-piperidin-4-ol is also used as a sedative agent for its calming effects, which can be beneficial in certain medical conditions requiring sedation.
Used in Addiction Treatment:
4-(3-Methoxy-phenyl)-piperidin-4-ol is used as a potential treatment for addiction, particularly opioid dependence, due to its agonist activity at the μ-opioid receptor. However, its use in this context must be carefully managed to avoid the risk of abuse and dependence.

180161-15-3

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180161-15-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 180161-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,1,6 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 180161-15:
(8*1)+(7*8)+(6*0)+(5*1)+(4*6)+(3*1)+(2*1)+(1*5)=103
103 % 10 = 3
So 180161-15-3 is a valid CAS Registry Number.

180161-15-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(3-Methoxyphenyl)piperidin-4-ol

1.2 Other means of identification

Product number -
Other names 4-(3-methoxyphenyl)piperidin-4-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:180161-15-3 SDS

180161-15-3Relevant academic research and scientific papers

INDOLE DERIVATIVE AND USE FOR TREATMENT OF CANCER

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Page/Page column 256, (2010/02/15)

The present invention relates to a compound represented by the formula (I’) wherein A is a benzene ring optionally having substituents, R1, R2a and R3 are each a hydrogen atom, a hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, R1 and R2a may form a ring via X, when R1 and R2a form a ring via X, R1 and R2a are each a bond or a divalent C1-5 acyclic hydrocarbon group optionally having substituents, and X is a bond, an oxygen atom, an optionally oxidized sulfur atom or an imino group optionally having a substituent, provided that R1, R2a and X are not bonds at the same time, or a salt thereof, and an agent for inhibiting kinase (phosphorylation enzyme), which contains this compound or a prodrug thereof. The compound of the present invention has an inhibitory activity against kinase such as a vascular endothelial growth factor receptor (VEGFR) and the like, and is useful as an agent for the prophylaxis or threatment of cancer and the like.

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

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Page/Page column 14, (2008/06/13)

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.

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