180194-49-4Relevant academic research and scientific papers
Catalysis and regioselectivity in the Michael addition of azoles. Kinetic vs. thermodynamic control
Horvath, Andras
, p. 4423 - 4426 (1996)
Bicyclic guanidine bases, TBD and MTBD were found to be high]y efficient catalysts in the Michael addition of azoles with α,β-unsaturated nitriles and esters. The factors influencing regioselectivity have been elucidated, and some new azole-Michael adduct
Substituted imidazole-1-vinyl compound and use thereof
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Paragraph 0056; 0088-0091, (2016/10/27)
The invention relates to a substituted imidazole-1-ethylene compound as well as a preparation and an application thereof. The substituted imidazole-1-ethylene compound is a compound shown as a formula I, or salts thereof formed with medicinal acids or bases. According to the antifungal activity test performed on eight clinical fungi by the compound provided in the invention, a good fungus killing effect is achieved. The compound can serve as a novel broad-spectrum antifungal activity compound and is developed into antifungal medicines, disinfectants or feed additives.
Farnesyl protein transferase inhibitors
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, (2008/06/13)
Disclosed are compounds of the formula: wherein R13represents an imidazole ring; R14represents a carbamate, urea, amide or sulfonamide group; R8represents H when the alkyl chain between the amide group and the R13imidazole group is substituted, or R8represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8is H, and the alkyl chain between the amide group and the R13imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
