180197-39-1Relevant academic research and scientific papers
Palladium-Catalyzed Synthesis of Isoquinolinones via Sequential Cyclization and N-O Bond Cleavage of N -Methoxy- o -alkynylbenzamides
Jithunsa, Manita,Ueda, Masafumi,Aoi, Naoki,Sugita, Shoichi,Miyoshi, Tetsuya,Miyata, Okiko
, p. 475 - 478 (2013)
A palladium-catalyzed controlled 6-endo-dig cyclization process has been developed for the chemoselective synthesis of isoquinolin-1-ones from N-alkoxy-o-alkynylbenzamides. The mechanism and scope of the reaction have also been investigated. Deuterium-labeling studies were used to confirm the intramolecular 1,5-hydrogen shift as a key step in the transformation. Georg Thieme Verlag Stuttgart · New York.
