180198-63-4

Upstream product

• 180198-60-1 2,4-Dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine-9-carbaldehyde 
• 142271-98-5 2,4-dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine 
• 603-35-0 triphenylphosphine 
• 180198-62-3 (Z)-2-Azido-3-(2,4-dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridin-9-yl)-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Preparation of aza-analogs of aplysinopsins and zwitterionic by reactions of heterocumulenes in naphthyridine's series

Imidazo[1,2-a][1,8]naphthyridines (9a,b) having the carbodiimide moiety on the position 1 lead to (Z)-aza-aplysinopsins (10a,b) by solid supported reaction on neutral alumina. By flash chromatography these heterocumulenes are stereospecifically converted to the corresponding methoxyimidazol-4-ones (11a,b) in good yields. In contrast, tandem aza-Wittig-cyclization reaction of imidazo[1,2-a][1,8]naphthyridine (13) having iminophosphorane moiety on the position 2 gives zwitterionic compounds (14a,b, 15) by N-annulation under thermal conditions.