180202-82-8Relevant academic research and scientific papers
Substituted azetidin-2-ones for treatment of atherosclerosis
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, (2008/06/13)
Compounds of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen, halogen or C(1-8) alkyl; R3 is aryl or aryl C(1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA2 and thereof of use in treating atherosclerosis.
