18028-51-8Relevant academic research and scientific papers
Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers
Zhang, Feng,Zaidi, Saheem,Haney, Kendra M.,Kellogg, Glen E.,Zhang, Yan
, p. 7945 - 7952 (2011/11/30)
The syntheses of the natural product anibamine and its three olefin isomers have been achieved concisely and efficiently via highly regio- and stereoselective reactions. The crucial steps included a regioselective palladium-catalyzed alkynylation by Sonogashira coupling and a stereoselective Suzuki coupling. Further conformation analyses and in vitro calcium mobilization studies were carried out to characterize the compounds' biological properties.
