180285-52-3Relevant academic research and scientific papers
Total synthesis of (+)-azinothricin and (+)-kettapeptin
Hale, Karl J.,Manaviazar, Soraya,George, Jonathan H.,Walters, Marcus A.,Dalby, Stephen M.
supporting information; experimental part, p. 733 - 736 (2009/09/30)
(Chemical Equation Presented) Asymmetric total syntheses of (+)-azinothricin and (+)-kettapeptin have been completed through a common new pathway that exploits a highly chemoselective coupling reaction between the fully elaborated cyclodepsipeptide 5 and the glycal activated esters 3 and 4 at the final stages of both respective syntheses.
Synthetic studies on the azinothricin family of antitumour antibiotics. 5. Asymmetric synthesis of two activated esters for the northern sector of A83586C
Hale, Karl J.,Cai, Jiaqiang
, p. 4233 - 4236 (2007/10/03)
An asymmeric synthesis of the activated esters 20 and 21 is reported. Both molecules equate with the C(28)-C(47) region of A83586C, and contain functionality appropriate for future unification with the hexapeptide unit. A useful new reaction is described for converting a methyl ester directly into a thioethyl or HOBT ester that operates under very mild conditions.
