18029-54-4

Usage

Uses

Used in Chemical Reactions:
5-[3-(dimethylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol is used as a reducing agent in chemical reactions, facilitating the transfer of electrons and promoting the reduction of other compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-[3-(dimethylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol is used as an intermediate in the synthesis of various drugs, such as 5-Hydroxy-N-methylprotriptyline and Cyclobenzaprine USP Related Compound A. Its unique structure and properties make it a valuable component in the development of new medications with potential therapeutic benefits.

InChI:InChI=1/C20H23NO/c1-21(2)15-7-14-20(22)18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)20/h3-6,8-13,22H,7,14-15H2,1-2H3

Upstream product

• 109-54-6 3-(Dimethylamino)propyl chloride 
• 2222-33-5 dibenzosuberenon 

Downstream Products

• 438-60-8 Protriptylin 
• 303-53-7 Cyclobenzaprine 
• 16234-93-8 5-<3-(N-Carbethoxy-N-methyl.-amino)-propyl>-dibenzocyclohepten-5-ol 
• 521-80-2 N,N-dimethyl-3-(5H-dibenzo[a,d]cyclohepten-5-yl)-propylamine 

Relevant academic research and scientific papers

Synthesis method of cyclobenzaprine hydrochloride

The invention discloses a synthesis method of cyclobenzaprine hydrochloride, and the method comprises: taking 7-10 ml of redistilled tetrahydrofuran, placing the redistilled tetrahydrofuran into a 100ml three-necked bottle, adding 1-2 pieces of iodine particles, 3-5 drops of 1, 2-dibromoethane and 0.7-1.0 g of zinc powder, slowly heating to a temperature of 35 DEG C, and carrying out a constant temperature reaction for 30-40 min. N, N-dimethyl-3-chloro-zinc propylamine is synthesized from N, N-dimethyl-3-chloropropylamine, iodine, 1,2-dibromoethane and zinc powder in tetrahydrofuran, then cyclobenzaprine is synthesized from the N, N-dimethyl-3-chloro-zinc propylamine and 5 H-dibenzo [a, d] cycloheptatriene-5-one, the cyclobenzaprine hydrochloride is synthesized from the cyclobenzaprine, the quality and purity of the cyclobenzaprine hydrochloride are improved by combination of the cyclobenzaprine and a stirring reaction device, a reaction control technology and a washing purification method. The synthetic reaction process is mild, the safety is high, the product yield is high and the purity of the target product is high. The method is simple and feasible, simple, fast, efficient and energy-saving, and is suitable for industrial mass production.

ONE-POT PREPARATION OF CYCLOBENZAPRINE HYDROCHLORIDE

Disclosed herein is a one-pot process for the preparation of pharmaceutically active cyclobenzaprine hydrochloride (Formula I) which comprises, reacting 5-dibenzosuberenone with Grignard reagent derived from 3-dimethylaminopropyl chloride. The reaction ma

A chemoselective deoxygenation of N-oxides by sodium borohydride-Raney nickel in water

A simple and convenient protocol for deoxygenation of aliphatic and aromatic N-oxides to the corresponding amines in good to excellent yield using sodium borohydride-Raney nickel in water is reported. Other functional moieties such as alkenes, halides, ethers, and amides are unaffected under the present reaction condition.