180293-94-1

Upstream product

• 128461-58-5 (4S,5R)-4-Methyl-3-(pent-4-enoyl)-5-phenyl-1,3-oxazolidin-2-one 
• 177031-11-7 (4S,5R)-3-<3-(3,4-Dimethoxyphenyl)propanoyl>-4-methyl-5-phenyl-1,3-oxazolidin-2-one 

Downstream Products

• 180293-96-3 (S)-3-(Benzyloxycarbonylamino-methyl)-4-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid methyl ester 
• 180293-95-2 (R)-3-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-pentanedioic acid monomethyl ester 

Relevant academic research and scientific papers

Enantioselective synthesis of (S)-2-(aminomethyl)butanedioic acid using chiral β-alanine α-enolate equivalents

(S)-2-(Aminomethyl)butanedioic acid (6) can been synthesised by stereoselective alkylation of the Na enolates of acyloxazolidinones 1a and 1b with methyl bromoacetate, then oxidation of the vinyl or dimethoxyphenyl substituent to a carboxyl group, followed by Curtius rearrangement and deprotection. The absolute configuration of 6 has been correlated with that of (S)-1-phenylethylamine by a combination of crystallographic and chemical means.