180293-97-4

Upstream product

• 180293-96-3 (S)-3-(Benzyloxycarbonylamino-methyl)-4-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid methyl ester 
• 180293-95-2 (R)-3-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-pentanedioic acid monomethyl ester 
• 100-51-6 benzyl alcohol 

Downstream Products

• 428518-31-4 methyl (R)-(-)-5-oxo-3-pyrrolidinecarboxylate 
• 428518-31-4 methyl (S)-(-)-5-oxo-3-pyrrolidinecarboxylate 

Relevant academic research and scientific papers

Enantioselective synthesis of (S)-2-(aminomethyl)butanedioic acid using chiral β-alanine α-enolate equivalents

(S)-2-(Aminomethyl)butanedioic acid (6) can been synthesised by stereoselective alkylation of the Na enolates of acyloxazolidinones 1a and 1b with methyl bromoacetate, then oxidation of the vinyl or dimethoxyphenyl substituent to a carboxyl group, followed by Curtius rearrangement and deprotection. The absolute configuration of 6 has been correlated with that of (S)-1-phenylethylamine by a combination of crystallographic and chemical means.