18032-57-0Relevant academic research and scientific papers
A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate
Zhu, Xizhen,Kreutter, Kevin D.,Hu, Huaping,Player, Mark R.,Gaul, Micheal D.
, p. 832 - 834 (2008/04/13)
A novel reagent combination, Tf2O/Na2CO3·1.5H2O2, has been developed for the oxidation of highly electron deficient pyridines to their corresponding N-oxides. The N-oxidation reaction, utilizing the in situ generated peracid, proceeds under mild conditions that allow for a number of functional groups and substitution patterns on the pyridine ring.
Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls
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Page/Page column 9; 10, (2008/06/13)
The present invention describes compounds of Formula I or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal. The present invention also relates to a novel method of N-oxidation of nitrogen containing heteroaryls.
