(S)-5-fluoro-3-methylisobenzofuran-1(3H)-one is a chiral organic compound characterized by the presence of a fluorine atom and a methyl group attached to an isobenzofuran-1(3H)-one core. It exhibits a specific stereochemistry, with the S-configuration, which is crucial for its biological activity and applications.
1803573-19-4
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Basic information
- Product Name: (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one
- Synonyms: (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one;1803573-19-4;(3S)-5-fluoro-3-methyl-3H-2-benzofuran-1-one;SCHEMBL24223347;DTXSID601021067;AMY25499;WS-01050;C92544;1(3H)-Isobenzofuranone, 5-fluoro-3-methyl-, (3S)-
- CAS NO:1803573-19-4
- Molecular Formula: C9H7FO2
- Molecular Weight: 166.15
- EINECS: 943-180-4
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one(CAS DataBase Reference)
- NIST Chemistry Reference: (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one(1803573-19-4)
- EPA Substance Registry System: (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one(1803573-19-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1803573-19-4(Hazardous Substances Data)
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1803573-19-4 Usage
Uses
Used in Pharmaceutical Industry:(S)-5-fluoro-3-methylisobenzofuran-1(3H)-one is used as a key chiral intermediate for the synthesis of Lorlatinib (PF-06463922), a third-generation anaplastic lymphoma kinase (ALK) inhibitor. (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one plays a vital role in the development of targeted cancer therapies, particularly for the treatment of non-small cell lung cancer (NSCLC) patients with ALK-positive mutations. Its unique stereochemistry ensures the desired biological activity and selectivity of the final drug product, contributing to improved patient outcomes and treatment options.
Appearence
(S)-5-fluoro-3-methylisobenzofuran-1(3H)-one is a white to Light Yellow Solid.Check Digit Verification of cas no
The CAS Registry Mumber 1803573-19-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,3,5,7 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.Calculate Digit Verification of CAS Registry Number 1803573-19:
(9*1)+(8*8)+(7*0)+(6*3)+(5*5)+(4*7)+(3*3)+(2*1)+(1*9)=164
164 % 10 = 4
So 1803573-19-4 is a valid CAS Registry Number.
1803573-19-4Upstream product
1803573-19-4Downstream Products
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(S)-5-fluoro-3-methylisobenzofuran-1(3H)-one
