180402-92-0Relevant academic research and scientific papers
Synthesis and properties of new 2-alkyl-1,4-benzoxazepine derivatives. Part I. Synthesis and cyclization of 2-phenoxyalkanoic acid derivatives
Kwiecien
, p. 733 - 741 (2007/10/03)
2-Alkyl-1,4-benzoxazepin-3,5-diones (8) were readily prepared by cyclodehydration of 2-(o-carbamoilphenoxy)alkanoic acids (7) in acetic anhydride, and with low yields by the same reaction of 2-(o-carboxyphenoxy)alkanoic acid amides (4). The novel acid amides 4 were synthesized from salicylaldehyde and 2-bromo esters 1, via formyl amides 3. The acid amides 7 were formed directly by condensation of salicylamides with 2-bromo esters 1 in dimethyl formamide or by hydrolysis of esters 6 obtained by the same reaction in methyl-ethyl ketone solution.
