18041-82-2Relevant academic research and scientific papers
Crystal structures of atisine 15-acetoxyazomethine and 15-hydroxyazomethine and their biological activities
Salimov,Tashkhodzhaev,Kodirova,Tursunkhodzhaeva,Dzhakhangirov
, p. 261 - 264 (2011)
The 15-acetoxyazomethine derivative of atisine was prepared from atisine base. Its structure was confirmed by converting it to atisine 15-hydroxyazomethine and proved by an XSA. Atisine 15-acetoxyazomethine exhibited antiarrhythmic activity in rat cardiac arrhythmia models induced by CaCl2 and aconitine. Atisine 15-acetoxyazomethine, in contrast with atisine 15-hydroxyazomethine, exhibited local anesthetic activity.
Formation, reactions, and NMR spectra of 1,20-cycloatidanes
Edwards, Oliver E.,Dvornik, Dusan,Kolt, Ralph J.,Blackwell, Barbara A.
, p. 1397 - 1405 (2007/10/02)
Imines derived from the alkaloid atisine gave N-acetyl 1,20-cycloatidane derivatives when heated with acetic anhydride.Vigorous alkaline hydrolysis cleaved the cyclopropane ring, regenerating the parent imine.The 1H and 13C NMR spectra of several 1,20-cyclo derivatives have been assigned and compared to those of the parent imines 2.All of the N-acetyl compounds showed doubling of the majority of the NMR resonances, due to amide rotamers.The effects of the cyclopropane ring current are noted.
