180412-87-7Relevant academic research and scientific papers
Synthesis of the antitumor antibiotic FR-66979: Dmitrienko oxidative expansion of a fully functional core structure
Lim, Hee-Jong,Sulikowski, Gary A.
, p. 5243 - 5246 (2007/10/03)
A stereocontrolled synthesis of the pentacyclic ring system 18, a projected advanced intermediate in the synthesis of FR-66979 (2), has been achieved. Key steps in the assembly of 18 include a copper(I) mediated cylization-oxidation of diazoketone 6 to mitosene 16 followed by an oxidative expansion of 16 to 18. The latter transformation proceeds via N-oxidation of diol 17.
