180475-94-9Relevant academic research and scientific papers
Aryl H-Phosphonates. 12. Synthetic and 31P NMR Studies on the Preparation of Nucleoside H-Phosphonothioate and Nucleoside H-Phosphonodithioate Monoesters
Cieslak, Jacek,Jankowska, Jadwiga,Stawinski, Jacek,Kraszewski, Adam
, p. 7049 - 7054 (2007/10/03)
Transformation of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioate and H-phosphonodithioate derivatives and possible side-reactions that may accompany this process were studied using 31P NMR spectroscopy. These provided new insight into a possible mechanism involved in this transformation and constituted the basis for development of efficient methods for the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters using readily available H-phosphonate monoesters as starting materials.
Aryl H-phosphonates. Part IV. A new method for internucleotide bond formation based on transesterification of aryl nucleoside H-phosphonate diesters
Cieslak, Jacek,Sobkowski, Michal,Kraszewski, Adam,Stawinski, Jacek
, p. 4561 - 4564 (2007/10/03)
Under mild reaction conditions nucleoside aryl H-phosphonate diesters undergo fast and efficient transesterification with suitably protected nucleosides, affording dinucleoside (3'-5') H-phosphonate diesters.
