180479-37-2

Upstream product

• 180479-30-5 (3S,4R,5R)-1-(4-Methoxy-benzyl)-5-methyl-3,4-bis-triisopropylsilanyloxy-pyrrolidin-2-one 
• 180479-36-1 (3S,4R,5R)-3,4-Dihydroxy-1-(4-methoxy-benzyl)-5-methyl-pyrrolidin-2-one 
• 180479-31-6 (3S,4R,5R)-3,4-Bis-benzyloxy-1-(4-methoxy-benzyl)-5-methyl-pyrrolidin-2-one 

Downstream Products

• 180479-32-7 (2R,3R,4S)-3,4-Bis-benzyloxy-2-methyl-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 180581-37-7 [(1R,2R,3R,4S)-2,3-Bis-benzyloxy-4-hydroxy-4-(4-methoxy-phenyl)-1-methyl-butyl]-carbamic acid tert-butyl ester 
• 180479-34-9 (2R,3R,4R,5R)-3,4-Bis-benzyloxy-2-(4-methoxy-phenyl)-5-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of natural (-)-codonopsinine employing stereoselective reduction of quaternary α-hydroxypyrrolidine

A novel and efficient process is described for the total synthesis of a dihydroxypyrrolidine alkaloid, (-)-codonopsinine in 33% overall yield. The synthetic strategy is based on the stereoselective reduction of an α-hydroxypyrrolidine intermediate, elaborated through asymmetric deoxygenation of a homochiral quaternary α-hydroxylactam.