180480-03-9

Upstream product

• 50-00-0 formaldehyd 
• 180480-02-8 (3aS,8aR,3'aR,8'aS)-8,8'-Dibenzyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl] 
• 261350-20-3 1,1’-dibenzyl-3,3’-bis(2-hydroxyethyl)[3,3’-biindoline]-2,2’-dione 
• 180479-96-3 (E)-1,1'-dibenzyl-[3,3'-biindolinylidene]-2,2'-dione 
• 180480-01-7 C₃₄H₃₆N₄O 
• 180479-99-6 C₃₄H₃₄N₂O₃ 
• 180479-97-4 C₃₄H₂₈N₂O₂ 
• 180479-98-5 C₃₄H₃₀N₂O 
• 247061-37-6 C₃₄H₃₂N₈O 

Relevant academic research and scientific papers

Development of catalytic deacylative alkylations (DaA) of 3-acyl-2-oxindoles: total synthesis of meso-chimonanthine and related alkaloids

We present an effective deacylative alkylation strategy for the construction of a variety of 2-oxindoles bearing an all-carbon quaternary center at the pseudobenzylic position. A wide variety of products with quaternary centers could be accessed by employing simple Pd(0) catalysis under mild reaction conditions. Importantly, the same strategy works equally well for the dimeric 2-oxindole system, furnishing products with a vicinal quaternary center in favour of meso-isomer as the major product. Eventual application to the total syntheses of meso-chimonanthine and meso-folicanthine very well demonstrates the synthetic potential of this strategy.