180519-10-2Relevant academic research and scientific papers
PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS
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Page/Page column 210, (2009/10/22)
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein the variables A, L1, L2, R2, R11, and M are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
