18052-88-5

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 694-53-1 phenylsilane 
• 615-37-2 ortho-methylphenyl iodide 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 201216-21-9 phenyl-m-tolyl-o-tolyl-silane 
• 18751-19-4 [3-(2-chloro-phenyl)-propyl]-phenyl-o-tolyl-silane 
• 18858-67-8 (4-phenoxy-phenyl)-phenyl-o-tolyl-silane 
• 18834-12-3 (4-phenoxy-phenyl)-phenyl-o-tolyl-p-tolyl-silane 
• 18758-55-9 methyl-(4-phenoxy-phenyl)-phenyl-o-tolyl-silane 
• 18870-37-6 phenyl-m-tolyl-o-tolyl-p-tolyl-silane 

Relevant academic research and scientific papers

Silylation of Aryl Halides with Monoorganosilanes Activated by Lithium Alkoxide

Lithium alkoxide activates a monoorganosilane to generate a transient LiH/alkoxysilane complex, which quickly reacts with aryl and alkenyl halides at 25 °C to deliver a diorganosilane product. Experimental and theoretical studies suggest that the reaction includes nucleophilic attack of LiH on the halogen atom of the organic halide to generate a transient organolithium/alkoxysilane intermediate, which undergoes quick carbon-silicon bond formation within the complex.

Acceleration of the substitution of silanes with Grignard reagents by using either LiCl or YCl3/MeLi

Getting up to speed: Both LiCl and the YCl3/MeLi catalyst system have an acceleration effect upon the substitution of silanes using Grignard reagents (see scheme). The method provides access to benzyl-, allyl-, and arylsilanes in good yields from the starting silanes.