180572-69-4

Basic information

• Product Name: diethyl <1-(1-hydroxy-3-chloro-2-cyclohexen-1-yl)ethyl>phosphonate
• Synonyms: diethyl <1-(1-hydroxy-3-chloro-2-cyclohexen-1-yl)ethyl>phosphonate
• CAS NO: 180572-69-4
• Molecular Weight: 296.731
• Mol File: 180572-69-4.mol

Chemical Properties

• CAS DataBase Reference: diethyl <1-(1-hydroxy-3-chloro-2-cyclohexen-1-yl)ethyl>phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl <1-(1-hydroxy-3-chloro-2-cyclohexen-1-yl)ethyl>phosphonate(180572-69-4)
• EPA Substance Registry System: diethyl <1-(1-hydroxy-3-chloro-2-cyclohexen-1-yl)ethyl>phosphonate(180572-69-4)

Safety Data

• Hazardous Substances Data: 180572-69-4(Hazardous Substances Data)

Upstream product

• 5682-75-7 3-chloro-2-cyclohexenone 
• 78-38-6 ethylphosphonic acid diethyl ester 

Downstream Products

• 173171-34-1 diethyl <1-(3-oxo-1-cyclohexen-1-yl)ethyl>phosphonate 

Relevant articles and documents

Reaction of Phosphonate-Stabilized Carbanions with Cyclic Enones Bearing a β-Leaving Group

Reaction between α-lithiated alkylphosphonic esters and α,β-unsaturated cyclopentenones and cyclohexenones carrying a heteroatom substituent Y in the β-position was studied.Complete chemoselectivity was observed as a function of substituent Y.For Y = OMe exclusive addition-elimination at the β-carbon was observed, yielding α,β-unsaturated δ-ketophosphonates.The β-chloro-substituted substrates (Y = Cl) derived from cyclohexenone reacted exclusively at the carbonyl carbon, yielding (2-hydroxyalkyl)phosphonates with the retained chlorovinyl function.The alcohols, depending on the conditions, could be dehydrated to two different products.The reaction of 3-chlorocyclopent-2-en-1-one with diethyl (lithiomethyl)phosphonate occured at the β-carbon, but the ketophosphonate product was isolated in a stable enolic form.