180587-74-0

Usage

Uses

Used in Pharmaceutical Research:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is used as a research tool for studying purinergic signaling, which plays a crucial role in various physiological and pathological processes. Understanding the effects of (R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol on purinergic signaling can help in the development of new therapeutic agents targeting these pathways.
Used in Synthesis of Nucleoside Analogs:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is used as a building block in the synthesis of nucleoside analogs, which are important in the development of antiviral and anticancer drugs. Its unique structure allows for the creation of novel nucleoside analogs with potential therapeutic applications.
Used in Cancer Research:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is being investigated for its potential as an anti-cancer agent. Its effects on adenosine receptors and other molecular targets may provide insights into the development of new cancer therapies.
Used in Drug Development:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol's potential pharmacological properties make it a valuable candidate for drug development. Its interactions with adenosine receptors and other molecular targets can be further explored to develop new drugs with improved efficacy and safety profiles.

Upstream product

• 87-42-3 6-chloropurine 
• 100682-42-6 1-(6-chloro-9H-purin-9-yl)-2-propanone 
• 122-51-0 orthoformic acid triethyl ester 
• 17435-30-2 (R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol 

Downstream Products

• 14047-28-0 (R)-9-(2-hydroxypropyl)adenine 
• 147127-20-6 tenofovir 
• 180587-75-1 (R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 

Relevant academic research and scientific papers

Preparation method for tenofovir

The invention relates to the field of chemical synthesis, and in particular relates to a preparation method for tenofovir. The compound provided by the invention has a structure shown by a formula XIIin the description. The method for preparing the tenofovir based on a compound provided by the invention has the advantages that raw materials are cheap and easy to obtain, the process route is short, the conditions are mild and reliable, and the method is easily used for industrialized production.

(R)- (+) - 9 - (2 - hydroxypropyl) adenine preparation method

The invention discloses a preparation method of (R)-(+)-9-(2-hydroxypropyl) adenine, which is a key intermediate for tenofovir disoproxil fumarate. The method comprises the following steps: (1) reacting 6-chloropurine and bromopropanone to obtain 6-chloro-9-(acetonyl)-purine; (2) performing an asymmetric hydrogenation reduction reaction of the resultant 6-chloro-9-(acetonyl)-purine to obtain (R)-(+)-6-chloro-9-(2-hydroxypropyl) adenine; and (3) performing an aminolysis reaction of the resultant (R)-(+)-6-chloro-9-(2-hydroxypropyl) adenine to obtain (R)-(+)-9-(2-hydroxypropyl) adenine. An achiral compound, cheap and easy to obtain, is taken as a raw material in the method; the reaction steps are small; the reaction is easy to deal with; the enantioselectivity of the product is high; and the yield is high, and thus the preparation method has industrialization value.

The synthesis of tenofovir and its analogues via asymmetric transfer hydrogenation

A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives. Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction steps. The present report suggests an efficient process to acquire tenofovir and its analogues.