180590-83-4Relevant academic research and scientific papers
Asymmetric synthesis of calyculin C. 1. Synthesis of the C1-C25 fragment
Scarlato, Gerard R.,DeMattei, John A.,Chong, Lee S.,Ogawa, Anthony K.,Lin, Mavis R.,Armstrong, Robert W.
, p. 6139 - 6152 (2007/10/03)
We report our synthesis of the C1-C25 fragment of serine/threonine phosphatase PP1 and PP2A inhibitor, calyculin C. Synthetic efforts were directed initially toward the synthesis of a spiroketal core fragment (7), which culminated in completion of the bottom half of the natural product. The synthesis of fragment 7 and subsequent elaboration relied on an allylboration strategy for introduction of chirality. The C1-C8 fragment representing the potentially unstable tetraene moiety was introduced as a separate entity.
